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Innovative Chemical Compound: 2-Chloro-5-chloromethylpyridine (CCMP)

Shandong Jihui Chemical Co., LTD : Deep cultivation of fine chemical industry, cast a diversified industrial pattern.

2-Fluoro-5-trifluoromethylpyridine

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Haloxyfop-P-methyl

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Picoxystrobin

2-Amino-3-chloro-5-trifluoromethylpyridine

2-Chloro-5-methylpyridine

3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-Amino-6-methylbenzenesulfonamide

[4-(4-Aminophenoxy)(2-pyridyl)]-2-methylcarboxamide

2-Fluoro-3-chloro-5-trifluoromethylpyridine

2,3-Dimethvl-6-nitroindazole

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one

2-Chloro-3-trichloromethylpyridine

2-Amino-5-methylpyridine

2-Fluoro-6-trifluoromethylpyridine

2-Amino-3-chloro-5-trifluoromethylpyridine

CAS: 79456-26-1

Chemical formula : C6H4ClF3N2

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Description

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2-Amino-3-chloro-5-trifluoromethylpyridine- Introduction

79456-26-1 – Names and Identifiers

Name	2-Amino-3-chloro-5-trifluoromethylpyridine
Synonyms	2,3,5-actf TIMTEC-BB SBB003584 LABOTEST-BB LT00012608 3-chloro-1,1,2,3,3-pentafluoroprop-1-ene 2-Amino-3-chloro-5-trifluoromethylpyridine 3-chloro-5-(trifluoromethyl)pyridin-2-amine 3-Chloro-5-(trifluoromethyl)-2-pyridylamine
CAS	79456-26-1
EINECS	401-670-0
InChI	InChI=1/C6H4ClF3N2/c7-4-1-3(6(8,9)10)2-12-5(4)11/h1-2H,(H2,11,12)
InChIKey	WXNPZQIRDCDLJD-UHFFFAOYSA-N

79456-26-1 – Physico-chemical Properties

Molecular Formula	C6H4ClF3N2
Molar Mass	196.56
Density	1.4650 (estimate)
Melting Point	86-90 °C (lit.)
Boling Point	205°C
Flash Point	75.71°C
Water Solubility	622mg/L at 25℃
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	40.8Pa at 24.85℃
Appearance	White crystal
Color	White to off-white
pKa	1.79±0.49(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Sensitive	Easily absorbing moisture
Refractive Index	1.502
MDL	MFCD00042154
Physical and Chemical Properties	Melting Point: 84-94°C Boiling Point: 205°C

79456-26-1 – Risk and Safety

Risk Codes	R22 – Harmful if swallowed R52/53 – Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38 – Irritating to eyes, respiratory system and skin. R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S61 – Avoid release to the environment. Refer to special instructions / safety data sheets. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S22 – Do not breathe dust.
WGK Germany	2
HS Code	29339900
Hazard Class	IRRITANT

79456-26-1 – Reference Information

LogP	2.59 at 20℃
Introduction	2-amino-3-chloro-5-trifluoromethyl pyridine, as a key intermediate in the preparation of fluroxamine. The production technology of fluxamine is a new technology for the production of a new type of substituted aniline broad-spectrum fungicide in the fine chemical industry of pesticide intermediates, at the same time, the effect of fluoride on a variety of Botrytis cinerea caused by Botrytis cinerea.
preparation	add 2-aminopyridine (9.4g,1.0mol) to MIBK(48ml), the mixture was stirred until dissolution was clear, and the temperature was lowered to -5 to 0 °c using an ice machine. NBS(18.2g,0.102mol) was dissolved in MIBK (ML) solvent. The NBS solution was added dropwise to the 2-aminopyridine solution at -5~5 ℃ for 1.5-2 hours, the pot temperature was controlled at -5 to 5 ° C. For 4 hours. The 2-aminopyridine content was 0.01% by liquid phase analysis. NCS(15.4g,0.115mol) was dissolved in MIBK(160mL), and the dissolved NCS solution was put into the reactor, and the temperature of the reactor was controlled to 90~100 ℃, The reaction was incubated for 15 hours, and the content of 2-amino-5-bromopyridine was 0.03% by liquid phase analysis. Distillation under reduced pressure, after removing more than 90% of MIBK solvent, add mixed solvent of ethanol (150mL) and water (15mL), heat up to 60~70 ℃, dissolve, recrystallize, filter and rinse, 2-amino-3-chloro-5-bromopyridine is obtained. The above 2-amino-3-chloro-5-bromopyridine solid was added to dioxane (162mL) and heated to 55-60 °c to dissolve, then PdCl2dppf catalyst (0.73g,0.001mol), potassium acetate (14.7g,0.15mol) and ch3bf3 K(19.4g,0.11mol), controlled the kettle temperature at 80~100 ℃ for 12 hours, liquid phase analysis the 2-amino-3-chloro-5-bromopyridine content was 0.05%. The reaction solution is reduced to room temperature, Suction filtration, dioxane washing, distillation of solvent, activated carbon decolorization, Ethanol and heptane (1/5 volume ratio) were slurried and dried to give 2-amino-3-chloro-5-trifluoromethylpyridine (13.9g).