2-Chloro-4-trifluoromethylpyridine

CAS: 81565-18-6

Molecular Formula: C6H3ClF3N

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Description

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2-Chloro-4-trifluoromethylpyridine – Introduction

81565-18-6 – Names and Identifiers

Name	2-Chloro-4-trifluoromethylpyridine
Synonyms	oro-4-(trifL 2-Chloro-4-(trifluor 2-Chloro-4-(trifluoromethyl)pyridine 2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE Pyridine,2-chloro-4-(trifluoromethyl)- ethyl [2-(trifluoromethyl)phenyl]acetate 2-Chloro-alpha,alpha,alpha-trifluoro-4-picoline
CAS	81565-18-6
EINECS	617-242-3
InChI	InChI=1/C11H11F3O2/c1-2-16-10(15)7-8-5-3-4-6-9(8)11(12,13)14/h3-6H,2,7H2,1H3

81565-18-6 – Physico-chemical Properties

Molecular Formula	C6H3ClF3N
Molar Mass	181.54
Density	1.411g/mLat 25°C(lit.)
Melting Point	-19°C
Boling Point	146-147°C(lit.)
Flash Point	127°F
Solubility	Chloroform, Methanol (Sparingly)
Vapor Presure	0.0688mmHg at 25°C
Appearance	Oil
Color	Colourless
BRN	4246276
pKa	-1.34±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	n20/D 1.4490(lit.)
Physical and Chemical Properties	Melting Point -19°C boiling point 146-147°C(lit.) density 1.411g/mL at 25°C(lit.) refractive index n20/D 1.4490(lit.) flash point 127 °F BRN 4246276

81565-18-6 – Risk and Safety

Risk Codes	R10 – Flammable R36/37/38 – Irritating to eyes, respiratory system and skin. R25 – Toxic if swallowed R11 – Highly Flammable
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S22 – Do not breathe dust. S16 – Keep away from sources of ignition.
UN IDs	UN 1993 3/PG 3
WGK Germany	3
HS Code	29333990
Hazard Note	Irritant
Hazard Class	3
Packing Group	III

81565-18-6 – Introduction

2-Chloro-4-(trifluoromethyl)pyridine is an organic compound with the formula C6H3ClF3N. The following is an introduction to its nature, use, preparation and safety information:

Nature:
-Appearance: 2-Chloro-4-(trifluoromethyl)pyridine is a colorless liquid.
-Melting point:-3 ℃
-Boiling point: 98 ℃
-Density: 1.50g/cm³
-Solubility: It is insoluble in water, but can be dissolved in organic solvents.

Use:
– 2-Chloro-4-(trifluoromethyl)pyridine can be used as an important intermediate in organic synthesis. It is widely used in the fields of drugs, dyes and pesticides.
-It can also be used to prepare other organic compounds, such as heterocyclic compounds and crown ether derivatives.

Preparation Method:
2-Chloro-4-(trifluoromethyl)pyridine can be prepared by reacting 2-chloro-4-nitropyridine with trifluoromethyl fluoroformate under basic conditions. The reaction process is usually carried out at low temperature.

Safety Information:
– 2-Chloro-4-(trifluoromethyl)pyridine is an organic compound with certain toxicity and irritation. Use should follow appropriate laboratory procedures and take necessary safety measures, such as wearing protective glasses, gloves and laboratory coats.
-Avoid contact with skin, eyes and respiratory tract. If exposed to this substance, immediately flush the affected area with plenty of flowing water and seek medical help.
-Store in a closed container, away from fire and oxidizing agents.