2-Fluoro-5-trifluoromethylpyridine

CAS: 69045-82-5

Molecular Formula: C6H3F4N

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Description

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2-Fluoro-5-trifluoromethylpyridine – Introduction

69045-82-5 – Names and Identifiers

Name	2-Fluoro-5-trifluoromethylpyridine
Synonyms	uoro-6-(trifL 2-Fluoro-5-(Trichloromethyl)Py 2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Pyridine, 2-fluoro-5-(trifluoroMethyl)-
CAS	69045-82-5
EINECS	400-290-2
InChI	InChI=1/C6H3F4N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H

69045-82-5 – Physico-chemical Properties

Molecular Formula	C6H3F4N
Molar Mass	165.09
Density	1.368 g/mL at 25 °C
Boling Point	118-122℃
Flash Point	35°(95°F)
Vapor Presure	9.61mmHg at 25°C
pKa	-2.86±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.4020
MDL	MFCD07437945

69045-82-5 – Risk and Safety

Risk Codes	R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 – Irritating to eyes, respiratory system and skin. R52/53 – Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R43 – May cause sensitization by skin contact R10 – Flammable
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 – Avoid release to the environment. Refer to special instructions / safety data sheets. S37 – Wear suitable gloves. S24 – Avoid contact with skin. S36 – Wear suitable protective clothing. S27 – Take off immediately all contaminated clothing.
UN IDs	1993
WGK Germany	3
HS Code	29333990
Hazard Note	Irritant
Hazard Class	3
Packing Group	Ⅲ

69045-82-5 – Reference Information

application

2-fluoro-5-trifluoromethylpyridine is an important chemical intermediate raw material. by introducing fluorine atoms into pyridine ring and pyridine side chain, it has strong lipophilicity and can play an important role in pesticides and medicine. its application value and market prospect are very considerable.

Preparation method

The synthesis steps of 2-fluoro-5-trifluoromethylpyridine:(1) Using 3-methylpyridine as raw material, one-step chlorination Synthesis of 2-chloro-5-trichloromethylpyridine crude product;(2) Using purified 2-chloro-5-trichloromethylpyridine as raw material, using anhydrous HF as a fluorination reagent, one-step fluorination synthesis of 2-fluoro-5-trifluoromethylpyridine crude;(3) the oil layer after alkali washing and water washing, after decompression distillation to obtain high-purity 2-fluoro-5-trifluoromethylpyridine.

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