2-Fluoro-3-chloro-5-trifluoromethylpyridine

CAS: 72537-17-8

Molecular Formula: C6H2ClF4N

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2-Fluoro-3-chloro-5-trifluoromethylpyridine- Introduction

72537-17-8 – Names and Identifiers

Name	2-Fluoro-3-chloro-5-trifluoromethylpyridine
Synonyms	CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine Pyridine, 3-chloro-2-fluoro-5-(trifluoromethyl)- TIANFU-CHEM 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
CAS	72537-17-8
EINECS	625-955-6
InChI	InChI=1/C6H2ClF4N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H

72537-17-8 – Physico-chemical Properties

Molecular Formula	C6H2ClF4N
Molar Mass	199.53
Density	1.524 g/mL at 25 °C (lit.)
Melting Point	16-20 °C (lit.)
Boling Point	50-55 °C/11 mmHg (lit.)
Flash Point	125°F
Vapor Presure	3.944mmHg at 25°C
Appearance	Liquid
Color	Colorless
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	n20/D 1.433(lit.)

72537-17-8 – Risk and Safety

Hazard Symbols	Xi – Irritant
Risk Codes	R10 – Flammable R36/37/38 – Irritating to eyes, respiratory system and skin.
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing.
UN IDs	UN 1993 3/PG 3
WGK Germany	3
HS Code	29333990
Hazard Note	Irritant
Hazard Class	3.2
Packing Group	III

72537-17-8 – Introduction

3-choro-2-fluoro-5-(trifluoromethyl)-pyridine is an organic compound with the formula C6H2ClF4N and a molecular weight of 183.53.

The following is about the properties of 3-choro-2-fluoro-5-(trifluoromethyl)-pyridine:
1. Appearance: colorless to yellowish liquid or solid;
2. melting point:-3 ℃;
3. boiling point: 105 ℃(120 Pa);
4. Relative density: 1.69(20/4 ℃);
5. Refractive index: 1.4075(20 ℃);
6. Solubility: Soluble in many organic solvents, such as ethanol, ether and dichloromethane.

3-chloro-2-fluoro-5-(trifluoromethyl)-The main use of pyridine is as an important intermediate in organic synthesis. It can be used to synthesize organic compounds with biological activity, such as pesticides, pharmaceuticals and preservatives for agricultural products.

The method for preparing 3-chloro-2-fluoro-5-(trifluoromethyl)-pyridine is usually achieved by fluorination of pyridine. Specifically, 2-fluoro-5-chloropyridine can be reacted with a reagent such as trifluoromethylmagnesium bromide or trifluoromethylboron fluoride under appropriate conditions to give the target product.

Regarding the safety information of 3-chloro-2-fluoro-5-(trifluoromethyl)-pyridine, it is an organic compound with certain toxicity and corrosiveness. Therefore, in the use of the need to pay attention to the following matters:
1. Avoid contact with skin, eyes and respiratory tract. Wear protective gloves, goggles, masks and other personal protective equipment during use;
2. Operate in a well-ventilated place to avoid inhaling harmful gases;
3. Store away from fire and oxidant;
4. if accidental contact or inhalation, immediately rinse the affected area with plenty of water and seek medical help;
5. When disposing of waste, it is necessary to properly dispose of it in accordance with local environmental regulations.